What’s nicotinamide mononucleotide (NMN)?

What’s NMN? nicotinamide mononucleotide (NMN), a precursor for nicotinamide adenine dinucleotide (NAD+) (an integral player in many cell processes and maintaining our body’s established order), is being investigated in numerous numerous studies as well as other research to evaluate its use as an ingredient which may help combat various aging-related changes.

In 2018, with all the discharge of the 11th edition of the World Health Organization (WHO)’s ICD codes (International Classification of Diseases), age-related diseases were included like a disease state.

Classifying aging as a disease opened the threshold to analyze on various topics associated with boosting NAD+ in mammalian cells as well as the possible benefits of slowing down aging. NAD+ plays an integral role in many activities in the body that, with aging, decline. Studies show that NAD+ levels drop almost 50% after we reach middle age.

NMN benefits

Taken orally, NMN is proposed to become efficiently absorbed and changed into NAD+. Preliminary studies in mice and also other lab animals, using a number of recently conducted or still ongoing clinical tests, suggest that enhanced levels of NAD+ may suppress age-related inflammation in several tissues, support thinking processes, production and action of insulin, plus more. Additionally, possible advantages of NMN may include:

Support of cognitive function

Within a study by Shen et al., researchers demonstrated improved cognitive function and decreased depression-like behaviors in mice which were administered NMN.

Additional encouraging research suggests that NMN administration may provide several neuroprotective effects. However, further studies necessary to decide if these effects can also be affecting humans.

Potential role in aging

NMN skin benefits are being investigated, though studies are still inside their infancy.

In a 2021 study by Zhou et al., researchers evaluated NMN use in mice. They found improvement in sun-damaged aging-related skin changes. This might initiate further development and research of novel therapeutic methods, even preventing ultraviolet sun ray-related skin damage.

In the 2022 study by Brito et al., investigators evaluated and demonstrated NMN’s role in decreasing melanin (pigment). The study’s findings suggest therapeutic potential which might benefit those with age-related hyperpigmentation signs for example brown spots down the road.

Potential fertility support

Taking NMN may provide improvements in fertility in the men and women.

As women age, the high quality and quantity of their oocytes decline. Studies in mice have demostrated that NMN administration resulted in increased ovulation, improved oocyte maturation, and the power to achieve fertilization.

As men age, sperm production decreases. Early mouse studies advise that this decline in sperm production occurs secondary on the depleting amounts of NAD+ that accompanies aging. This might be supported by administering NMN which might improve sperm counts as men age.

Heart health benefits

By preserve NAD+ levels in the body, while aging, we may be capable of support heart health insurance and potentially reduce the risk of some heart diseases.

Amounts of NAD+ within the heart decrease with increasing age. Use of the NAD+ precursor, NMN, might help support healthy aging of arteries and might reduce circulatory stiffness. Heart protective benefits can include better hypertension control, fewer arrhythmias (abnormal heart rhythms), and in many cases improvements in overall heart function.

Metabolic health support

Decreased NAD+ levels are already identified in animals and humans with obesity, and the ones with diabetes. Several studies, including a mouse model by Uddin et al., claim that NMN administration not simply increases NAD+ levels but may also improve glucose clearance linked to high-fat diets bringing about obesity, diabetes, and aging. NMN may help in diabetes regulation and obesity management down the road.

Improve sleep

NMN may join melatonin and also other supplements to further improve sleep and sleep quality, minimizing insomnia as well as other sleep disorders.

Inside a study by Shen et al., researchers found that NMN be involved to maintain one’s circadian rhythm.

Other animal studies also reported that providing additional NMN was proven to improve the objective of the GABAergic system within the body – an important player in mood disorders, neurological disease, sleep regulation, and other components of health. Via modifications to this system along with other pathways, findings suggest the potential utilization of NMN administration may play a supportive role in sleep regulation.

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